Acute lymphocytic or lymphoblastic leukemia is sometimes called ALL. It starts in the bone marrow where blood cells are made. It is more common in children than in adults.
Target therapies toward specific transcripts eg, BCR-ABL1 tyrosine kinase oncoprotein by tyrosine kinase inhibitors and specific leukemic cell surface antigens eg, CD20, CD22, and CD19 monoclonal antibodies are major breakthroughs. Monoclonal antibodies, bispecific antibody constructs, and chimeric antigen receptor T cellular therapies developed in the past 5 to 7 years have revolutionized the treatment of ALL and resulted in US Food and Drug Administration approvals of blinatumomab inas well as inotuzumab and tisagenlecleucel in as ALL salvage strategies. Their use in combined modalities as salvage and frontline therapies is currently under investigation.
Acute lymphocytic leukemia ALL is a cancer of the blood and bone marrow. ALL is the most common childhood cancer. Children younger than age 5 have the highest risk.
Adult acute lymphoblastic leukemia ALL; also called acute lymphocytic leukemia is a cancer of the blood and bone marrow. This type of cancer usually gets worse quickly if it is not treated. Normally, the bone marrow makes blood stem cells immature cells that become mature blood cells over time. A blood stem cell may become a myeloid stem cell or a lymphoid stem cell.
Back to Health A to Z. Acute lymphoblastic leukaemia is a type of cancer that affects the white blood cells. It progresses rapidly and aggressively and requires immediate treatment.
Leukemia is cancer of the white blood cells. White blood cells help your body fight infection. Your blood cells form in your bone marrow.
This article is a more specific discussion of ALL. Please be sure to read Leukemia: The Basics first, so you have a basic understanding of leukemia. ALL is a blood cancer that affects the white blood cells.
Acute lymphocytic leukemia ALL is a type of cancer of the blood and bone marrow — the spongy tissue inside bones where blood cells are made. The word "acute" in acute lymphocytic leukemia comes from the fact that the disease progresses rapidly and creates immature blood cells, rather than mature ones. The word "lymphocytic" in acute lymphocytic leukemia refers to the white blood cells called lymphocytes, which ALL affects. Acute lymphocytic leukemia is also known as acute lymphoblastic leukemia.
Overview Adult ALL is a malignant disease or cancer of the blood characterized by the rapid uncontrolled growth of abnormal, immature white blood cells known as lymphoblasts. The development of cytogenetic and molecular tests can now better define prognostic groups allowing for individualized treatment regimens for patients with high- and low-risk features. The potential benefits of receiving cancer treatment must be carefully balanced with the potential risks of receiving cancer treatment.